Peripheral administration of antisense oligonucleotides targeting the amyloid-β protein precursor reverses AβPP and LRP-1 overexpression in the aged SAMP8 mouse brain.
Erickson, Michelle A
Peripheral administration of antisense oligonucleotides targeting the amyloid-β protein precursor reverses AβPP and LRP-1 overexpression in the aged SAMP8 mouse brain. [electronic resource] - Journal of Alzheimer's disease : JAD 2012 - 951-60 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
1875-8908
10.3233/JAD-2011-111517 doi
Aging--metabolism
Amyloid beta-Protein Precursor--antagonists & inhibitors
Animals
Brain--drug effects
Drug Delivery Systems
Gene Expression Regulation
Low Density Lipoprotein Receptor-Related Protein-1
Male
Mice
Mice, Transgenic
Oligonucleotides, Antisense--administration & dosage
Receptors, LDL--antagonists & inhibitors
Tumor Suppressor Proteins--antagonists & inhibitors
Peripheral administration of antisense oligonucleotides targeting the amyloid-β protein precursor reverses AβPP and LRP-1 overexpression in the aged SAMP8 mouse brain. [electronic resource] - Journal of Alzheimer's disease : JAD 2012 - 951-60 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
1875-8908
10.3233/JAD-2011-111517 doi
Aging--metabolism
Amyloid beta-Protein Precursor--antagonists & inhibitors
Animals
Brain--drug effects
Drug Delivery Systems
Gene Expression Regulation
Low Density Lipoprotein Receptor-Related Protein-1
Male
Mice
Mice, Transgenic
Oligonucleotides, Antisense--administration & dosage
Receptors, LDL--antagonists & inhibitors
Tumor Suppressor Proteins--antagonists & inhibitors