A polymeric nanoparticle encapsulated small-molecule inhibitor of Hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to Smoothened antagonists. [electronic resource]
Producer: 20120629Description: 165-73 p. digitalISSN:- 1538-8514
- Animals
- Cell Line, Tumor
- Cell Proliferation
- Deoxycytidine -- analogs & derivatives
- Hedgehog Proteins -- antagonists & inhibitors
- Humans
- Male
- Medulloblastoma -- metabolism
- Mice
- Mice, Nude
- Nanoparticles -- chemistry
- Pancreatic Neoplasms -- metabolism
- Patched Receptors
- Patched-1 Receptor
- Receptors, Cell Surface -- genetics
- Receptors, G-Protein-Coupled -- antagonists & inhibitors
- Signal Transduction
- Smoothened Receptor
- Transcription Factors -- antagonists & inhibitors
- Tumor Suppressor Protein p53 -- genetics
- Xenograft Model Antitumor Assays
- Zinc Finger Protein GLI1
- Gemcitabine
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Publication Type: Journal Article
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