A polymeric nanoparticle encapsulated small-molecule inhibitor of Hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to Smoothened antagonists.

Chenna, Venugopal

A polymeric nanoparticle encapsulated small-molecule inhibitor of Hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to Smoothened antagonists. [electronic resource] - Molecular cancer therapeutics Jan 2012 - 165-73 p. digital

Publication Type: Journal Article

1538-8514

10.1158/1535-7163.MCT-11-0341 doi


Animals
Cell Line, Tumor
Cell Proliferation
Deoxycytidine--analogs & derivatives
Hedgehog Proteins--antagonists & inhibitors
Humans
Male
Medulloblastoma--metabolism
Mice
Mice, Nude
Nanoparticles--chemistry
Pancreatic Neoplasms--metabolism
Patched Receptors
Patched-1 Receptor
Receptors, Cell Surface--genetics
Receptors, G-Protein-Coupled--antagonists & inhibitors
Signal Transduction
Smoothened Receptor
Transcription Factors--antagonists & inhibitors
Tumor Suppressor Protein p53--genetics
Xenograft Model Antitumor Assays
Zinc Finger Protein GLI1
Gemcitabine