Activation of NOX2 by the stimulation of ionotropic and metabotropic glutamate receptors contributes to glutamate neurotoxicity in vivo through the production of reactive oxygen species and calpain activation. [electronic resource]
Producer: 20111208Description: 1020-35 p. digitalISSN:- 1554-6578
- Animals
- Calcium-Binding Proteins -- metabolism
- Calpain -- metabolism
- Corpus Striatum -- drug effects
- Disease Models, Animal
- Drug Interactions
- Excitatory Amino Acid Agents -- pharmacology
- Fluoresceins
- Gene Expression Regulation -- drug effects
- Glutamic Acid -- toxicity
- Membrane Glycoproteins -- deficiency
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Microfilament Proteins -- metabolism
- Microglia -- drug effects
- NADPH Oxidase 2
- NADPH Oxidases -- deficiency
- Neurons -- drug effects
- Neurotoxicity Syndromes -- etiology
- Organic Chemicals
- Phosphopyruvate Hydratase -- metabolism
- Reactive Oxygen Species -- metabolism
- Receptors, Immunologic -- metabolism
- Receptors, Ionotropic Glutamate -- metabolism
- Receptors, Metabotropic Glutamate -- metabolism
- Time Factors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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