Activation of NOX2 by the stimulation of ionotropic and metabotropic glutamate receptors contributes to glutamate neurotoxicity in vivo through the production of reactive oxygen species and calpain activation.

Guemez-Gamboa, Alicia

Activation of NOX2 by the stimulation of ionotropic and metabotropic glutamate receptors contributes to glutamate neurotoxicity in vivo through the production of reactive oxygen species and calpain activation. [electronic resource] - Journal of neuropathology and experimental neurology Nov 2011 - 1020-35 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1554-6578

10.1097/NEN.0b013e3182358e4e doi


Animals
Calcium-Binding Proteins--metabolism
Calpain--metabolism
Corpus Striatum--drug effects
Disease Models, Animal
Drug Interactions
Excitatory Amino Acid Agents--pharmacology
Fluoresceins
Gene Expression Regulation--drug effects
Glutamic Acid--toxicity
Membrane Glycoproteins--deficiency
Mice
Mice, Inbred C57BL
Mice, Knockout
Microfilament Proteins--metabolism
Microglia--drug effects
NADPH Oxidase 2
NADPH Oxidases--deficiency
Neurons--drug effects
Neurotoxicity Syndromes--etiology
Organic Chemicals
Phosphopyruvate Hydratase--metabolism
Reactive Oxygen Species--metabolism
Receptors, Immunologic--metabolism
Receptors, Ionotropic Glutamate--metabolism
Receptors, Metabotropic Glutamate--metabolism
Time Factors