Genetic reduction of insulin-like growth factor-1 mimics the anticancer effects of calorie restriction on cyclooxygenase-2-driven pancreatic neoplasia. [electronic resource]
Producer: 20111115Description: 1030-40 p. digitalISSN:- 1940-6215
- Animals
- Anticarcinogenic Agents
- Blotting, Western
- Caloric Restriction
- Carcinoma, Pancreatic Ductal -- metabolism
- Cattle
- Cyclooxygenase 2 -- metabolism
- Female
- Immunoenzyme Techniques
- Insulin -- metabolism
- Insulin-Like Growth Factor I -- physiology
- Keratin-5 -- genetics
- Liver -- metabolism
- Male
- Mice
- Mice, Knockout
- Mice, Transgenic
- Pancreatic Neoplasms -- metabolism
- Phosphorylation
- Proto-Oncogene Proteins c-akt -- metabolism
- TOR Serine-Threonine Kinases -- metabolism
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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