Genetic reduction of insulin-like growth factor-1 mimics the anticancer effects of calorie restriction on cyclooxygenase-2-driven pancreatic neoplasia.
Lashinger, Laura M
Genetic reduction of insulin-like growth factor-1 mimics the anticancer effects of calorie restriction on cyclooxygenase-2-driven pancreatic neoplasia. [electronic resource] - Cancer prevention research (Philadelphia, Pa.) Jul 2011 - 1030-40 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1940-6215
10.1158/1940-6207.CAPR-11-0027 doi
Animals
Anticarcinogenic Agents
Blotting, Western
Caloric Restriction
Carcinoma, Pancreatic Ductal--metabolism
Cattle
Cyclooxygenase 2--metabolism
Female
Immunoenzyme Techniques
Insulin--metabolism
Insulin-Like Growth Factor I--physiology
Keratin-5--genetics
Liver--metabolism
Male
Mice
Mice, Knockout
Mice, Transgenic
Pancreatic Neoplasms--metabolism
Phosphorylation
Proto-Oncogene Proteins c-akt--metabolism
TOR Serine-Threonine Kinases--metabolism
Tumor Cells, Cultured
Genetic reduction of insulin-like growth factor-1 mimics the anticancer effects of calorie restriction on cyclooxygenase-2-driven pancreatic neoplasia. [electronic resource] - Cancer prevention research (Philadelphia, Pa.) Jul 2011 - 1030-40 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1940-6215
10.1158/1940-6207.CAPR-11-0027 doi
Animals
Anticarcinogenic Agents
Blotting, Western
Caloric Restriction
Carcinoma, Pancreatic Ductal--metabolism
Cattle
Cyclooxygenase 2--metabolism
Female
Immunoenzyme Techniques
Insulin--metabolism
Insulin-Like Growth Factor I--physiology
Keratin-5--genetics
Liver--metabolism
Male
Mice
Mice, Knockout
Mice, Transgenic
Pancreatic Neoplasms--metabolism
Phosphorylation
Proto-Oncogene Proteins c-akt--metabolism
TOR Serine-Threonine Kinases--metabolism
Tumor Cells, Cultured