The red wine polyphenol resveratrol shows promising potential for the treatment of nucleus pulposus-mediated pain in vitro and in vivo. [electronic resource]
Producer: 20120215Description: E1373-84 p. digitalISSN:- 1528-1159
- Adult
- Aged
- Analgesics -- pharmacology
- Animals
- Anti-Inflammatory Agents -- pharmacology
- Cells, Cultured
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Extracellular Signal-Regulated MAP Kinases -- metabolism
- Female
- Gene Expression Regulation -- drug effects
- Humans
- Inflammation Mediators -- metabolism
- Interleukin-1beta -- genetics
- Interleukin-6 -- genetics
- Interleukin-8 -- genetics
- Intervertebral Disc -- drug effects
- JNK Mitogen-Activated Protein Kinases -- metabolism
- Male
- Matrix Metalloproteinase 1 -- genetics
- Matrix Metalloproteinase 13 -- genetics
- Matrix Metalloproteinase 3 -- genetics
- Middle Aged
- NF-kappa B -- metabolism
- Pain -- drug therapy
- Pain Measurement
- RNA, Messenger -- metabolism
- Radiculopathy -- complications
- Rats
- Rats, Sprague-Dawley
- Resveratrol
- Signal Transduction -- drug effects
- Sirtuin 1 -- metabolism
- Stilbenes -- pharmacology
- Time Factors
- Toll-Like Receptor 2 -- drug effects
- Wine
- Young Adult
- p38 Mitogen-Activated Protein Kinases -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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