The red wine polyphenol resveratrol shows promising potential for the treatment of nucleus pulposus-mediated pain in vitro and in vivo.

Wuertz, Karin

The red wine polyphenol resveratrol shows promising potential for the treatment of nucleus pulposus-mediated pain in vitro and in vivo. [electronic resource] - Spine Oct 2011 - E1373-84 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1528-1159

10.1097/BRS.0b013e318221e655 doi


Adult
Aged
Analgesics--pharmacology
Animals
Anti-Inflammatory Agents--pharmacology
Cells, Cultured
Disease Models, Animal
Dose-Response Relationship, Drug
Extracellular Signal-Regulated MAP Kinases--metabolism
Female
Gene Expression Regulation--drug effects
Humans
Inflammation Mediators--metabolism
Interleukin-1beta--genetics
Interleukin-6--genetics
Interleukin-8--genetics
Intervertebral Disc--drug effects
JNK Mitogen-Activated Protein Kinases--metabolism
Male
Matrix Metalloproteinase 1--genetics
Matrix Metalloproteinase 13--genetics
Matrix Metalloproteinase 3--genetics
Middle Aged
NF-kappa B--metabolism
Pain--drug therapy
Pain Measurement
RNA, Messenger--metabolism
Radiculopathy--complications
Rats
Rats, Sprague-Dawley
Resveratrol
Signal Transduction--drug effects
Sirtuin 1--metabolism
Stilbenes--pharmacology
Time Factors
Toll-Like Receptor 2--drug effects
Wine
Young Adult
p38 Mitogen-Activated Protein Kinases--metabolism