2'-deoxy-2'-α-fluoro-2'-β-C-methyl 3',5'-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: discovery of PSI-352938. [electronic resource]
Producer: 20110314Description: 7376-80 p. digitalISSN:- 1464-3405
- Administration, Oral
- Animals
- Antiviral Agents -- chemistry
- Cell Line, Tumor
- Crystallography, X-Ray
- Cyclic P-Oxides -- chemistry
- Enzyme Inhibitors -- chemistry
- Hepacivirus -- enzymology
- Humans
- Molecular Conformation
- Nucleosides -- chemistry
- Nucleotides, Cyclic -- chemical synthesis
- Prodrugs -- chemistry
- Rats
- Structure-Activity Relationship
- Viral Nonstructural Proteins -- antagonists & inhibitors
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Publication Type: Journal Article
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