2'-deoxy-2'-α-fluoro-2'-β-C-methyl 3',5'-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: discovery of PSI-352938.

Reddy, P Ganapati

2'-deoxy-2'-α-fluoro-2'-β-C-methyl 3',5'-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: discovery of PSI-352938. [electronic resource] - Bioorganic & medicinal chemistry letters Dec 2010 - 7376-80 p. digital

Publication Type: Journal Article

1464-3405

10.1016/j.bmcl.2010.10.035 doi


Administration, Oral
Animals
Antiviral Agents--chemistry
Cell Line, Tumor
Crystallography, X-Ray
Cyclic P-Oxides--chemistry
Enzyme Inhibitors--chemistry
Hepacivirus--enzymology
Humans
Molecular Conformation
Nucleosides--chemistry
Nucleotides, Cyclic--chemical synthesis
Prodrugs--chemistry
Rats
Structure-Activity Relationship
Viral Nonstructural Proteins--antagonists & inhibitors