The PI-3 kinase-Akt-MDM2-survivin signaling axis in high-risk neuroblastoma: a target for PI-3 kinase inhibitor intervention. [electronic resource]
Producer: 20111003Description: 325-35 p. digitalISSN:- 1432-0843
- Animals
- Antineoplastic Agents -- antagonists & inhibitors
- Apoptosis -- drug effects
- Cell Line, Tumor
- Cell Movement -- drug effects
- Cell Proliferation -- drug effects
- Chromones -- antagonists & inhibitors
- Enzyme Inhibitors -- pharmacology
- Female
- Humans
- Inhibitor of Apoptosis Proteins -- metabolism
- Mice
- Mice, Nude
- Neuroblastoma -- drug therapy
- Oligopeptides -- antagonists & inhibitors
- Phosphoinositide-3 Kinase Inhibitors
- Phosphorylation -- drug effects
- Prodrugs -- pharmacology
- Protein Processing, Post-Translational -- drug effects
- Proto-Oncogene Proteins c-akt -- metabolism
- Proto-Oncogene Proteins c-mdm2 -- metabolism
- Random Allocation
- Signal Transduction -- drug effects
- Survivin
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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