The PI-3 kinase-Akt-MDM2-survivin signaling axis in high-risk neuroblastoma: a target for PI-3 kinase inhibitor intervention.
Peirce, Susan K
The PI-3 kinase-Akt-MDM2-survivin signaling axis in high-risk neuroblastoma: a target for PI-3 kinase inhibitor intervention. [electronic resource] - Cancer chemotherapy and pharmacology Aug 2011 - 325-35 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1432-0843
10.1007/s00280-010-1486-7 doi
Animals
Antineoplastic Agents--antagonists & inhibitors
Apoptosis--drug effects
Cell Line, Tumor
Cell Movement--drug effects
Cell Proliferation--drug effects
Chromones--antagonists & inhibitors
Enzyme Inhibitors--pharmacology
Female
Humans
Inhibitor of Apoptosis Proteins--metabolism
Mice
Mice, Nude
Neuroblastoma--drug therapy
Oligopeptides--antagonists & inhibitors
Phosphoinositide-3 Kinase Inhibitors
Phosphorylation--drug effects
Prodrugs--pharmacology
Protein Processing, Post-Translational--drug effects
Proto-Oncogene Proteins c-akt--metabolism
Proto-Oncogene Proteins c-mdm2--metabolism
Random Allocation
Signal Transduction--drug effects
Survivin
Tumor Burden--drug effects
Xenograft Model Antitumor Assays
The PI-3 kinase-Akt-MDM2-survivin signaling axis in high-risk neuroblastoma: a target for PI-3 kinase inhibitor intervention. [electronic resource] - Cancer chemotherapy and pharmacology Aug 2011 - 325-35 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1432-0843
10.1007/s00280-010-1486-7 doi
Animals
Antineoplastic Agents--antagonists & inhibitors
Apoptosis--drug effects
Cell Line, Tumor
Cell Movement--drug effects
Cell Proliferation--drug effects
Chromones--antagonists & inhibitors
Enzyme Inhibitors--pharmacology
Female
Humans
Inhibitor of Apoptosis Proteins--metabolism
Mice
Mice, Nude
Neuroblastoma--drug therapy
Oligopeptides--antagonists & inhibitors
Phosphoinositide-3 Kinase Inhibitors
Phosphorylation--drug effects
Prodrugs--pharmacology
Protein Processing, Post-Translational--drug effects
Proto-Oncogene Proteins c-akt--metabolism
Proto-Oncogene Proteins c-mdm2--metabolism
Random Allocation
Signal Transduction--drug effects
Survivin
Tumor Burden--drug effects
Xenograft Model Antitumor Assays