Potent mutagenicity of 3-methylindole requires pulmonary cytochrome P450-mediated bioactivation: a comparison to the prototype cigarette smoke mutagens B(a)P and NNK. [electronic resource]
Producer: 20110307Description: 1682-90 p. digitalISSN:- 1520-5010
- Animals
- Aryl Hydrocarbon Hydroxylases -- metabolism
- Benzo(a)pyrene -- chemistry
- Cells, Cultured
- Cytochrome P-450 Enzyme System -- genetics
- DNA Damage
- Humans
- Liver -- metabolism
- Lung -- enzymology
- Microsomes -- enzymology
- Mutagenicity Tests
- Mutagens -- chemistry
- Nitrosamines -- chemistry
- Rats
- Ribosomal Protein S9
- Ribosomal Proteins -- genetics
- Salmonella typhimurium -- drug effects
- Skatole -- chemistry
- Smoking
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Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
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