Potent mutagenicity of 3-methylindole requires pulmonary cytochrome P450-mediated bioactivation: a comparison to the prototype cigarette smoke mutagens B(a)P and NNK.

Weems, Jessica M

Potent mutagenicity of 3-methylindole requires pulmonary cytochrome P450-mediated bioactivation: a comparison to the prototype cigarette smoke mutagens B(a)P and NNK. [electronic resource] - Chemical research in toxicology Nov 2010 - 1682-90 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural

1520-5010

10.1021/tx100147z doi


Animals
Aryl Hydrocarbon Hydroxylases--metabolism
Benzo(a)pyrene--chemistry
Cells, Cultured
Cytochrome P-450 Enzyme System--genetics
DNA Damage
Humans
Liver--metabolism
Lung--enzymology
Microsomes--enzymology
Mutagenicity Tests
Mutagens--chemistry
Nitrosamines--chemistry
Rats
Ribosomal Protein S9
Ribosomal Proteins--genetics
Salmonella typhimurium--drug effects
Skatole--chemistry
Smoking