The μ-opioid receptor variant N190K is unresponsive to peptide agonists yet can be rescued by small-molecule drugs. [electronic resource]
Producer: 20101207Description: 837-45 p. digitalISSN:- 1521-0111
- Black or African American
- Amino Acid Substitution
- Cell Line
- Cholesterol, HDL -- blood
- Enkephalin, Ala(2)-MePhe(4)-Gly(5)- -- pharmacology
- Female
- Genes, Reporter
- Genotype
- Humans
- Luciferases -- biosynthesis
- Mutagenesis, Site-Directed
- Mutation, Missense
- Naloxone -- pharmacology
- Naltrexone -- pharmacology
- Narcotic Antagonists -- pharmacology
- Opioid Peptides -- pharmacology
- Peptides -- pharmacology
- Polymorphism, Single Nucleotide
- Protein Isoforms -- agonists
- Protein Transport
- Radioligand Assay
- Receptors, Opioid, mu -- agonists
- Signal Transduction
- White People
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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