The μ-opioid receptor variant N190K is unresponsive to peptide agonists yet can be rescued by small-molecule drugs.

Fortin, Jean-Philippe

The μ-opioid receptor variant N190K is unresponsive to peptide agonists yet can be rescued by small-molecule drugs. [electronic resource] - Molecular pharmacology Nov 2010 - 837-45 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1521-0111

10.1124/mol.110.064188 doi


Black or African American
Amino Acid Substitution
Cell Line
Cholesterol, HDL--blood
Enkephalin, Ala(2)-MePhe(4)-Gly(5)---pharmacology
Female
Genes, Reporter
Genotype
Humans
Luciferases--biosynthesis
Mutagenesis, Site-Directed
Mutation, Missense
Naloxone--pharmacology
Naltrexone--pharmacology
Narcotic Antagonists--pharmacology
Opioid Peptides--pharmacology
Peptides--pharmacology
Polymorphism, Single Nucleotide
Protein Isoforms--agonists
Protein Transport
Radioligand Assay
Receptors, Opioid, mu--agonists
Signal Transduction
White People