Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARα and CAR/PXR. [electronic resource]
Producer: 20101103Description: 787-98 p. digitalISSN:- 1432-0738
- Animals
- Apoptosis -- drug effects
- Body Weight -- drug effects
- Caprylates -- toxicity
- Cell Proliferation -- drug effects
- Constitutive Androstane Receptor
- Cytochrome P-450 Enzyme System -- metabolism
- DNA -- metabolism
- Environmental Pollutants -- toxicity
- Fluorocarbons -- toxicity
- Hepatocytes -- drug effects
- Hepatomegaly -- chemically induced
- Hypertrophy
- Liver -- enzymology
- Male
- Organ Size -- drug effects
- PPAR alpha -- metabolism
- Peroxisomes -- metabolism
- Pregnane X Receptor
- Rats
- Rats, Sprague-Dawley
- Receptors, Cytoplasmic and Nuclear -- metabolism
- Receptors, Steroid -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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