Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARα and CAR/PXR.

Elcombe, Clifford R

Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARα and CAR/PXR. [electronic resource] - Archives of toxicology Oct 2010 - 787-98 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1432-0738

10.1007/s00204-010-0572-2 doi


Animals
Apoptosis--drug effects
Body Weight--drug effects
Caprylates--toxicity
Cell Proliferation--drug effects
Constitutive Androstane Receptor
Cytochrome P-450 Enzyme System--metabolism
DNA--metabolism
Environmental Pollutants--toxicity
Fluorocarbons--toxicity
Hepatocytes--drug effects
Hepatomegaly--chemically induced
Hypertrophy
Liver--enzymology
Male
Organ Size--drug effects
PPAR alpha--metabolism
Peroxisomes--metabolism
Pregnane X Receptor
Rats
Rats, Sprague-Dawley
Receptors, Cytoplasmic and Nuclear--metabolism
Receptors, Steroid--metabolism