Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors. [electronic resource]
Producer: 20101123Description: 4376-81 p. digitalISSN:- 1464-3405
- Acetazolamide -- analogs & derivatives
- Animals
- Binding Sites
- Carbonic Anhydrase II -- antagonists & inhibitors
- Carbonic Anhydrase Inhibitors -- chemistry
- Computer Simulation
- Crystallography, X-Ray
- Humans
- Hydrophobic and Hydrophilic Interactions
- Mice
- Protein Isoforms -- antagonists & inhibitors
- Sulfonamides -- chemistry
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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