A kinase-dead knock-in mutation in mTOR leads to early embryonic lethality and is dispensable for the immune system in heterozygous mice. [electronic resource]
Producer: 20091130Description: 28 p. digitalISSN:- 1471-2172
- Animals
- B-Lymphocytes -- drug effects
- Carrier Proteins -- genetics
- Catalytic Domain -- genetics
- Cell Proliferation -- drug effects
- Cells, Cultured
- Embryonic Development -- genetics
- Gene Knock-In Techniques
- Heterozygote
- Immune System -- embryology
- Lymphocyte Activation -- drug effects
- Mice
- Mutation
- Phosphatidylinositol 3-Kinases -- immunology
- Phosphotransferases (Alcohol Group Acceptor) -- genetics
- Signal Transduction -- drug effects
- Sirolimus -- pharmacology
- T-Lymphocytes -- drug effects
- TOR Serine-Threonine Kinases
- Tacrolimus Binding Protein 1A -- antagonists & inhibitors
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Publication Type: Journal Article
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