A kinase-dead knock-in mutation in mTOR leads to early embryonic lethality and is dispensable for the immune system in heterozygous mice.

Shor, Boris

A kinase-dead knock-in mutation in mTOR leads to early embryonic lethality and is dispensable for the immune system in heterozygous mice. [electronic resource] - BMC immunology May 2009 - 28 p. digital

Publication Type: Journal Article

1471-2172

10.1186/1471-2172-10-28 doi


Animals
B-Lymphocytes--drug effects
Carrier Proteins--genetics
Catalytic Domain--genetics
Cell Proliferation--drug effects
Cells, Cultured
Embryonic Development--genetics
Gene Knock-In Techniques
Heterozygote
Immune System--embryology
Lymphocyte Activation--drug effects
Mice
Mutation
Phosphatidylinositol 3-Kinases--immunology
Phosphotransferases (Alcohol Group Acceptor)--genetics
Signal Transduction--drug effects
Sirolimus--pharmacology
T-Lymphocytes--drug effects
TOR Serine-Threonine Kinases
Tacrolimus Binding Protein 1A--antagonists & inhibitors