Site-specific antiatherogenic effect of the antioxidant ebselen in the diabetic apolipoprotein E-deficient mouse. [electronic resource]
Producer: 20090604Description: 823-30 p. digitalISSN:- 1524-4636
- Administration, Oral
- Animals
- Antioxidants -- administration & dosage
- Aorta, Abdominal -- drug effects
- Aorta, Thoracic -- drug effects
- Aortic Diseases -- etiology
- Apolipoproteins E -- deficiency
- Atherosclerosis -- etiology
- Azoles -- administration & dosage
- Cells, Cultured
- Diabetes Mellitus, Experimental -- complications
- Diabetic Angiopathies -- etiology
- Endothelial Cells -- drug effects
- Glutathione Peroxidase -- deficiency
- Humans
- I-kappa B Kinase -- metabolism
- Isoindoles
- JNK Mitogen-Activated Protein Kinases -- metabolism
- Macrophages -- drug effects
- Male
- Membrane Glycoproteins -- metabolism
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Muscle, Smooth, Vascular -- drug effects
- NADPH Oxidase 2
- NADPH Oxidases -- metabolism
- Organoselenium Compounds -- administration & dosage
- Phenotype
- Phosphorylation
- Receptor for Advanced Glycation End Products
- Receptors, Immunologic -- metabolism
- Time Factors
- Tumor Necrosis Factor-alpha -- metabolism
- Tyrosine -- analogs & derivatives
- Vascular Endothelial Growth Factor A -- metabolism
- Glutathione Peroxidase GPX1
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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