N-((8-hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2). [electronic resource]
Producer: 20090429Description: 6454-7 p. digitalISSN:- 1464-3405
- ADAM Proteins -- antagonists & inhibitors
- ADAMTS4 Protein
- ADAMTS5 Protein
- Acetamides -- chemical synthesis
- Animals
- Chemistry, Pharmaceutical -- methods
- Cytochrome P-450 CYP3A
- Cytochrome P-450 CYP3A Inhibitors
- Cytochrome P-450 Enzyme Inhibitors
- Drug Design
- Humans
- Inhibitory Concentration 50
- Microsomes, Liver -- drug effects
- Models, Chemical
- Osteoarthritis -- drug therapy
- Procollagen N-Endopeptidase -- metabolism
- Rats
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Publication Type: Journal Article
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