N-((8-hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2).
Gilbert, Adam M
N-((8-hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2). [electronic resource] - Bioorganic & medicinal chemistry letters Dec 2008 - 6454-7 p. digital
Publication Type: Journal Article
1464-3405
10.1016/j.bmcl.2008.10.065 doi
ADAM Proteins--antagonists & inhibitors
ADAMTS4 Protein
ADAMTS5 Protein
Acetamides--chemical synthesis
Animals
Chemistry, Pharmaceutical--methods
Cytochrome P-450 CYP3A
Cytochrome P-450 CYP3A Inhibitors
Cytochrome P-450 Enzyme Inhibitors
Drug Design
Humans
Inhibitory Concentration 50
Microsomes, Liver--drug effects
Models, Chemical
Osteoarthritis--drug therapy
Procollagen N-Endopeptidase--metabolism
Rats
N-((8-hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2). [electronic resource] - Bioorganic & medicinal chemistry letters Dec 2008 - 6454-7 p. digital
Publication Type: Journal Article
1464-3405
10.1016/j.bmcl.2008.10.065 doi
ADAM Proteins--antagonists & inhibitors
ADAMTS4 Protein
ADAMTS5 Protein
Acetamides--chemical synthesis
Animals
Chemistry, Pharmaceutical--methods
Cytochrome P-450 CYP3A
Cytochrome P-450 CYP3A Inhibitors
Cytochrome P-450 Enzyme Inhibitors
Drug Design
Humans
Inhibitory Concentration 50
Microsomes, Liver--drug effects
Models, Chemical
Osteoarthritis--drug therapy
Procollagen N-Endopeptidase--metabolism
Rats