A dominant-negative form of the major human abasic endonuclease enhances cellular sensitivity to laboratory and clinical DNA-damaging agents. [electronic resource]
Producer: 20070301Description: 61-70 p. digitalISSN:- 1541-7786
- Amino Acid Substitution
- Animals
- Antineoplastic Agents -- pharmacology
- Binding Sites
- CHO Cells
- Carcinoma, Non-Small-Cell Lung -- drug therapy
- Cells, Cultured
- Cricetinae
- Cricetulus
- DNA -- genetics
- DNA Damage -- drug effects
- DNA Repair -- drug effects
- DNA, Neoplasm -- drug effects
- DNA-(Apurinic or Apyrimidinic Site) Lyase -- genetics
- Genes, Dominant
- Humans
- Hydrogen Peroxide -- pharmacology
- Lung Neoplasms -- drug therapy
- Methyl Methanesulfonate -- pharmacology
- Oxidants -- pharmacology
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Publication Type: Journal Article; Research Support, N.I.H., Intramural
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