A dominant-negative form of the major human abasic endonuclease enhances cellular sensitivity to laboratory and clinical DNA-damaging agents.

McNeill, Daniel R

A dominant-negative form of the major human abasic endonuclease enhances cellular sensitivity to laboratory and clinical DNA-damaging agents. [electronic resource] - Molecular cancer research : MCR Jan 2007 - 61-70 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Intramural

1541-7786

10.1158/1541-7786.MCR-06-0329 doi


Amino Acid Substitution
Animals
Antineoplastic Agents--pharmacology
Binding Sites
CHO Cells
Carcinoma, Non-Small-Cell Lung--drug therapy
Cells, Cultured
Cricetinae
Cricetulus
DNA--genetics
DNA Damage--drug effects
DNA Repair--drug effects
DNA, Neoplasm--drug effects
DNA-(Apurinic or Apyrimidinic Site) Lyase--genetics
Genes, Dominant
Humans
Hydrogen Peroxide--pharmacology
Lung Neoplasms--drug therapy
Methyl Methanesulfonate--pharmacology
Oxidants--pharmacology