Impact of cremophor-EL and polysorbate-80 on digoxin permeability across rat jejunum: delineation of thermodynamic and transporter related events using the reciprocal permeability approach. [electronic resource]
Producer: 20070410Description: 280-93 p. digitalISSN:- 0022-3549
- ATP Binding Cassette Transporter, Subfamily B, Member 1 -- antagonists & inhibitors
- Adenosine Triphosphatases -- antagonists & inhibitors
- Animals
- Digoxin -- metabolism
- Glycerol -- analogs & derivatives
- In Vitro Techniques
- Intestinal Absorption -- drug effects
- Intestinal Mucosa -- metabolism
- Jejunum -- metabolism
- Male
- Permeability -- drug effects
- Polysorbates -- pharmacology
- Rats
- Rats, Sprague-Dawley
- Serous Membrane -- metabolism
- Surface-Active Agents -- pharmacology
- Thermodynamics
- Vanadates -- pharmacology
- Verapamil -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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