Impact of cremophor-EL and polysorbate-80 on digoxin permeability across rat jejunum: delineation of thermodynamic and transporter related events using the reciprocal permeability approach.

Katneni, Kasiram

Impact of cremophor-EL and polysorbate-80 on digoxin permeability across rat jejunum: delineation of thermodynamic and transporter related events using the reciprocal permeability approach. [electronic resource] - Journal of pharmaceutical sciences Feb 2007 - 280-93 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-3549

10.1002/jps.20779 doi


ATP Binding Cassette Transporter, Subfamily B, Member 1--antagonists & inhibitors
Adenosine Triphosphatases--antagonists & inhibitors
Animals
Digoxin--metabolism
Glycerol--analogs & derivatives
In Vitro Techniques
Intestinal Absorption--drug effects
Intestinal Mucosa--metabolism
Jejunum--metabolism
Male
Permeability--drug effects
Polysorbates--pharmacology
Rats
Rats, Sprague-Dawley
Serous Membrane--metabolism
Surface-Active Agents--pharmacology
Thermodynamics
Vanadates--pharmacology
Verapamil--pharmacology