Defective one- or two-electron reduction of the anticancer anthracycline epirubicin in human heart. Relative importance of vesicular sequestration and impaired efficiency of electron addition. [electronic resource]
Producer: 20060613Description: 10990-1001 p. digitalISSN:- 0021-9258
- Aconitate Hydratase -- metabolism
- Adenosine Triphosphatases -- chemistry
- Aged
- Antibiotics, Antineoplastic -- pharmacology
- Antineoplastic Agents -- pharmacology
- Area Under Curve
- Cell Line, Tumor
- Cell Membrane -- metabolism
- Cell-Free System
- Cells, Cultured
- Cytoplasm -- metabolism
- Dose-Response Relationship, Drug
- Electrons
- Epirubicin -- chemistry
- Female
- Fluorescent Dyes -- pharmacology
- Humans
- Hydrogen Peroxide -- chemistry
- Inhibitory Concentration 50
- Kinetics
- Macrolides -- chemistry
- Male
- Microscopy, Confocal
- Microscopy, Fluorescence
- Middle Aged
- Mitochondria -- metabolism
- Models, Chemical
- Myocardium -- metabolism
- Oxidation-Reduction
- Oxygen -- metabolism
- Protein Biosynthesis
- Protons
- Reactive Oxygen Species
- Time Factors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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