Defective one- or two-electron reduction of the anticancer anthracycline epirubicin in human heart. Relative importance of vesicular sequestration and impaired efficiency of electron addition.

Salvatorelli, Emanuela

Defective one- or two-electron reduction of the anticancer anthracycline epirubicin in human heart. Relative importance of vesicular sequestration and impaired efficiency of electron addition. [electronic resource] - The Journal of biological chemistry Apr 2006 - 10990-1001 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9258

10.1074/jbc.M508343200 doi


Aconitate Hydratase--metabolism
Adenosine Triphosphatases--chemistry
Aged
Antibiotics, Antineoplastic--pharmacology
Antineoplastic Agents--pharmacology
Area Under Curve
Cell Line, Tumor
Cell Membrane--metabolism
Cell-Free System
Cells, Cultured
Cytoplasm--metabolism
Dose-Response Relationship, Drug
Electrons
Epirubicin--chemistry
Female
Fluorescent Dyes--pharmacology
Humans
Hydrogen Peroxide--chemistry
Inhibitory Concentration 50
Kinetics
Macrolides--chemistry
Male
Microscopy, Confocal
Microscopy, Fluorescence
Middle Aged
Mitochondria--metabolism
Models, Chemical
Myocardium--metabolism
Oxidation-Reduction
Oxygen--metabolism
Protein Biosynthesis
Protons
Reactive Oxygen Species
Time Factors