Interactive effects of HDAC inhibitors and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in multiple myeloma. [electronic resource]
Producer: 20050929Description: 646-57 p. digitalISSN:- 1522-8002
- Amino Acid Chloromethyl Ketones -- pharmacology
- Annexin A5 -- pharmacology
- Apoptosis
- Apoptosis Regulatory Proteins
- Calpain -- metabolism
- Caspases -- metabolism
- Cell Cycle -- drug effects
- Cell Cycle Proteins -- metabolism
- Cell Line, Tumor
- Cell Proliferation
- Cyclin-Dependent Kinase Inhibitor p27
- DNA-Binding Proteins -- metabolism
- Dose-Response Relationship, Drug
- Down-Regulation
- E2F Transcription Factors
- Enzyme Inhibitors -- pharmacology
- Flow Cytometry
- G1 Phase
- Gene Expression Regulation, Neoplastic
- Histone Deacetylase Inhibitors
- Histones -- metabolism
- Humans
- Immunoblotting
- Inhibitory Concentration 50
- Leupeptins -- pharmacology
- Luciferases -- metabolism
- Membrane Glycoproteins -- metabolism
- Membrane Potentials
- Microscopy, Fluorescence
- Mitochondria -- metabolism
- Multiple Myeloma -- metabolism
- NF-kappa B -- metabolism
- Phosphorylation
- Propidium -- pharmacology
- Protein Binding
- Ribonucleases -- metabolism
- Subcellular Fractions -- metabolism
- TNF-Related Apoptosis-Inducing Ligand
- Time Factors
- Transcription Factors -- metabolism
- Tumor Necrosis Factor-alpha -- metabolism
- Tumor Suppressor Proteins -- metabolism
- Up-Regulation
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Publication Type: Journal Article
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