Interactive effects of HDAC inhibitors and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in multiple myeloma.

Fandy, Tamer E

Interactive effects of HDAC inhibitors and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in multiple myeloma. [electronic resource] - Neoplasia (New York, N.Y.) Jul 2005 - 646-57 p. digital

Publication Type: Journal Article

1522-8002

10.1593/neo.04655 doi


Amino Acid Chloromethyl Ketones--pharmacology
Annexin A5--pharmacology
Apoptosis
Apoptosis Regulatory Proteins
Calpain--metabolism
Caspases--metabolism
Cell Cycle--drug effects
Cell Cycle Proteins--metabolism
Cell Line, Tumor
Cell Proliferation
Cyclin-Dependent Kinase Inhibitor p27
DNA-Binding Proteins--metabolism
Dose-Response Relationship, Drug
Down-Regulation
E2F Transcription Factors
Enzyme Inhibitors--pharmacology
Flow Cytometry
G1 Phase
Gene Expression Regulation, Neoplastic
Histone Deacetylase Inhibitors
Histones--metabolism
Humans
Immunoblotting
Inhibitory Concentration 50
Leupeptins--pharmacology
Luciferases--metabolism
Membrane Glycoproteins--metabolism
Membrane Potentials
Microscopy, Fluorescence
Mitochondria--metabolism
Multiple Myeloma--metabolism
NF-kappa B--metabolism
Phosphorylation
Propidium--pharmacology
Protein Binding
Ribonucleases--metabolism
Subcellular Fractions--metabolism
TNF-Related Apoptosis-Inducing Ligand
Time Factors
Transcription Factors--metabolism
Tumor Necrosis Factor-alpha--metabolism
Tumor Suppressor Proteins--metabolism
Up-Regulation