Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity. [electronic resource]
Producer: 20050922Description: 1315-28 p. digitalISSN:- 0022-3042
- Amino Acid Sequence
- Amyloid Precursor Protein Secretases
- Animals
- Aspartic Acid Endopeptidases -- metabolism
- Cells, Cultured
- Drug Stability
- Endopeptidases
- Endoplasmic Reticulum -- metabolism
- Fibroblasts -- enzymology
- Homeostasis -- physiology
- Humans
- Membrane Glycoproteins -- metabolism
- Membrane Proteins -- genetics
- Mice
- Mice, Knockout
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Presenilin-1
- Protein Structure, Tertiary -- physiology
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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