Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity.

Brunkan, A L

Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity. [electronic resource] - Journal of neurochemistry Sep 2005 - 1315-28 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0022-3042

10.1111/j.1471-4159.2005.03278.x doi


Amino Acid Sequence
Amyloid Precursor Protein Secretases
Animals
Aspartic Acid Endopeptidases--metabolism
Cells, Cultured
Drug Stability
Endopeptidases
Endoplasmic Reticulum--metabolism
Fibroblasts--enzymology
Homeostasis--physiology
Humans
Membrane Glycoproteins--metabolism
Membrane Proteins--genetics
Mice
Mice, Knockout
Molecular Sequence Data
Mutagenesis, Site-Directed
Presenilin-1
Protein Structure, Tertiary--physiology