Targeting 2A protease by RNA interference attenuates coxsackieviral cytopathogenicity and promotes survival in highly susceptible mice. [electronic resource]
Producer: 20051028Description: 1583-92 p. digitalISSN:- 1524-4539
- Animals
- Cell Survival -- drug effects
- Coxsackievirus Infections -- drug therapy
- Cysteine Endopeptidases -- genetics
- Drug Delivery Systems
- Enterovirus -- enzymology
- Gene Expression Regulation, Viral -- drug effects
- HeLa Cells
- Humans
- Mice
- Mice, Knockout
- RNA Interference
- RNA, Small Interfering -- pharmacology
- Receptors, Interferon -- deficiency
- Survival Rate
- Transfection
- Treatment Outcome
- Viral Proteins -- antagonists & inhibitors
- Virulence
- Virus Replication -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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