Targeting 2A protease by RNA interference attenuates coxsackieviral cytopathogenicity and promotes survival in highly susceptible mice.

Merl, Sabine

Targeting 2A protease by RNA interference attenuates coxsackieviral cytopathogenicity and promotes survival in highly susceptible mice. [electronic resource] - Circulation Apr 2005 - 1583-92 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1524-4539

10.1161/01.CIR.0000160360.02040.AB doi


Animals
Cell Survival--drug effects
Coxsackievirus Infections--drug therapy
Cysteine Endopeptidases--genetics
Drug Delivery Systems
Enterovirus--enzymology
Gene Expression Regulation, Viral--drug effects
HeLa Cells
Humans
Mice
Mice, Knockout
RNA Interference
RNA, Small Interfering--pharmacology
Receptors, Interferon--deficiency
Survival Rate
Transfection
Treatment Outcome
Viral Proteins--antagonists & inhibitors
Virulence
Virus Replication--drug effects