Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis. [electronic resource]
Producer: 20041026Description: 2766-74 p. digitalISSN:- 0004-3591
- Adult
- Aged
- Aged, 80 and over
- Antirheumatic Agents -- metabolism
- Arthritis, Rheumatoid -- drug therapy
- Carrier Proteins -- genetics
- Cross-Sectional Studies
- Erythrocytes -- chemistry
- Female
- Humans
- Hydroxymethyl and Formyl Transferases -- genetics
- Male
- Membrane Proteins -- genetics
- Membrane Transport Proteins -- genetics
- Methotrexate -- analogs & derivatives
- Middle Aged
- Multienzyme Complexes -- genetics
- Nucleotide Deaminases -- genetics
- Phosphoribosylaminoimidazolecarboxamide Formyltransferase
- Polyglutamic Acid -- analogs & derivatives
- Polymorphism, Genetic
- Reduced Folate Carrier Protein
- Thymidylate Synthase -- genetics
- Treatment Outcome
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Publication Type: Journal Article
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