Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis.

Dervieux, Thierry

Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis. [electronic resource] - Arthritis and rheumatism Sep 2004 - 2766-74 p. digital

Publication Type: Journal Article

0004-3591

10.1002/art.20460 doi


Adult
Aged
Aged, 80 and over
Antirheumatic Agents--metabolism
Arthritis, Rheumatoid--drug therapy
Carrier Proteins--genetics
Cross-Sectional Studies
Erythrocytes--chemistry
Female
Humans
Hydroxymethyl and Formyl Transferases--genetics
Male
Membrane Proteins--genetics
Membrane Transport Proteins--genetics
Methotrexate--analogs & derivatives
Middle Aged
Multienzyme Complexes--genetics
Nucleotide Deaminases--genetics
Phosphoribosylaminoimidazolecarboxamide Formyltransferase
Polyglutamic Acid--analogs & derivatives
Polymorphism, Genetic
Reduced Folate Carrier Protein
Thymidylate Synthase--genetics
Treatment Outcome