Proteosomal degradation of BCR/ABL protein can generate an HLA-A*0301-restricted peptide, but high-avidity T cells recognizing this leukemia-specific antigen were not demonstrated. [electronic resource]
Producer: 20060426Description: 1062-71 p. digitalISSN:- 1592-8721
- Amino Acid Sequence
- Antigen Presentation
- Antigens, Neoplasm -- immunology
- Clone Cells -- immunology
- Dendritic Cells -- immunology
- Fusion Proteins, bcr-abl -- immunology
- HLA-A Antigens -- immunology
- HLA-A3 Antigen
- HLA-B Antigens -- immunology
- HLA-B8 Antigen
- Humans
- K562 Cells
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- immunology
- Mass Spectrometry
- Molecular Sequence Data
- Peptide Fragments -- chemical synthesis
- Proteasome Endopeptidase Complex -- metabolism
- Protein Binding
- Protein Interaction Mapping
- T-Cell Antigen Receptor Specificity
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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