Proteosomal degradation of BCR/ABL protein can generate an HLA-A*0301-restricted peptide, but high-avidity T cells recognizing this leukemia-specific antigen were not demonstrated.

Posthuma, Eduardus F M

Proteosomal degradation of BCR/ABL protein can generate an HLA-A*0301-restricted peptide, but high-avidity T cells recognizing this leukemia-specific antigen were not demonstrated. [electronic resource] - Haematologica Sep 2004 - 1062-71 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

1592-8721


Amino Acid Sequence
Antigen Presentation
Antigens, Neoplasm--immunology
Clone Cells--immunology
Dendritic Cells--immunology
Fusion Proteins, bcr-abl--immunology
HLA-A Antigens--immunology
HLA-A3 Antigen
HLA-B Antigens--immunology
HLA-B8 Antigen
Humans
K562 Cells
Leukemia, Myelogenous, Chronic, BCR-ABL Positive--immunology
Mass Spectrometry
Molecular Sequence Data
Peptide Fragments--chemical synthesis
Proteasome Endopeptidase Complex--metabolism
Protein Binding
Protein Interaction Mapping
T-Cell Antigen Receptor Specificity