Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site. [electronic resource]
Producer: 20040830Description: 4147-50 p. digitalISSN:- 0022-2623
- Amino Acid Motifs
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins
- Carrier Proteins -- chemistry
- Caspase 9
- Caspases -- metabolism
- Cell Line, Tumor
- Cyclization
- Heterocyclic Compounds, 2-Ring -- chemical synthesis
- Humans
- Intracellular Signaling Peptides and Proteins
- Mitochondrial Proteins -- chemistry
- Models, Molecular
- Molecular Conformation
- Molecular Mimicry
- Oligopeptides -- chemistry
- Protein Binding
- Protein Structure, Tertiary
- Proteins -- metabolism
- Structure-Activity Relationship
- X-Linked Inhibitor of Apoptosis Protein
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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