Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site.

Sun, Haiying

Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site. [electronic resource] - Journal of medicinal chemistry Aug 2004 - 4147-50 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-2623

10.1021/jm0499108 doi


Amino Acid Motifs
Apoptosis--drug effects
Apoptosis Regulatory Proteins
Carrier Proteins--chemistry
Caspase 9
Caspases--metabolism
Cell Line, Tumor
Cyclization
Heterocyclic Compounds, 2-Ring--chemical synthesis
Humans
Intracellular Signaling Peptides and Proteins
Mitochondrial Proteins--chemistry
Models, Molecular
Molecular Conformation
Molecular Mimicry
Oligopeptides--chemistry
Protein Binding
Protein Structure, Tertiary
Proteins--metabolism
Structure-Activity Relationship
X-Linked Inhibitor of Apoptosis Protein