Strong inhibition of TNF-alpha production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor. [electronic resource]
Producer: 20050218Description: R384-92 p. digitalISSN:- 1478-6362
- Cell Differentiation -- drug effects
- Cells, Cultured
- Cyclooxygenase 2
- Cytokines -- biosynthesis
- Gene Expression Regulation -- drug effects
- Gene Expression Regulation, Enzymologic -- drug effects
- Imidazoles -- pharmacology
- Interleukin-8 -- genetics
- Intracellular Signaling Peptides and Proteins
- Isoenzymes -- genetics
- MAP Kinase Signaling System -- drug effects
- Macrophages -- enzymology
- Matrix Metalloproteinases -- biosynthesis
- Mitogen-Activated Protein Kinases
- Monocytes -- enzymology
- Phosphorylation -- drug effects
- Prostaglandin-Endoperoxide Synthases -- genetics
- Protein Serine-Threonine Kinases -- metabolism
- Pyridines -- pharmacology
- RNA, Messenger -- biosynthesis
- Tumor Necrosis Factor-alpha -- antagonists & inhibitors
- p38 Mitogen-Activated Protein Kinases -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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