Strong inhibition of TNF-alpha production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor.

Westra, Johanna

Strong inhibition of TNF-alpha production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor. [electronic resource] - Arthritis research & therapy 2004 - R384-92 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1478-6362

10.1186/ar1204 doi


Cell Differentiation--drug effects
Cells, Cultured
Cyclooxygenase 2
Cytokines--biosynthesis
Gene Expression Regulation--drug effects
Gene Expression Regulation, Enzymologic--drug effects
Imidazoles--pharmacology
Interleukin-8--genetics
Intracellular Signaling Peptides and Proteins
Isoenzymes--genetics
MAP Kinase Signaling System--drug effects
Macrophages--enzymology
Matrix Metalloproteinases--biosynthesis
Mitogen-Activated Protein Kinases
Monocytes--enzymology
Phosphorylation--drug effects
Prostaglandin-Endoperoxide Synthases--genetics
Protein Serine-Threonine Kinases--metabolism
Pyridines--pharmacology
RNA, Messenger--biosynthesis
Tumor Necrosis Factor-alpha--antagonists & inhibitors
p38 Mitogen-Activated Protein Kinases--antagonists & inhibitors