A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase. [electronic resource]
Producer: 19921228Description: 4450-4 p. digitalISSN:- 0022-2623
- Animals
- Antineoplastic Agents -- chemical synthesis
- Glutamates -- chemical synthesis
- Guanine -- analogs & derivatives
- Humans
- Leukemia L1210 -- drug therapy
- Leukemia, Lymphoid -- drug therapy
- Mice
- Pemetrexed
- Structure-Activity Relationship
- Thymidylate Synthase -- antagonists & inhibitors
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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