A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase. (Record no. 1454234)

MARC details
000 -LEADER
fixed length control field 01596 a2200421 4500
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20250511184438.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 199212s 0 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 0022-2623
024 7# - OTHER STANDARD IDENTIFIER
Standard number or code 10.1021/jm00101a023
Source of number or code doi
040 ## - CATALOGING SOURCE
Original cataloging agency NLM
Language of cataloging eng
Transcribing agency NLM
100 1# - MAIN ENTRY--PERSONAL NAME
Personal name Taylor, E C
264 #0 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE
Date of production, publication, distribution, manufacture, or copyright notice 19921228
245 00 - TITLE STATEMENT
Title A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-[2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo[2,3-d]pyrimidin-5- yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase.
Medium [electronic resource]
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. Journal of medicinal chemistry
Date of publication, distribution, etc. Nov 1992
300 ## - PHYSICAL DESCRIPTION
Extent 4450-4 p.
Other physical details digital
500 ## - GENERAL NOTE
General note Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Animals
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Antineoplastic Agents
General subdivision chemical synthesis
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Glutamates
General subdivision chemical synthesis
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Guanine
General subdivision analogs & derivatives
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Humans
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Leukemia L1210
General subdivision drug therapy
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Leukemia, Lymphoid
General subdivision drug therapy
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Mice
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Pemetrexed
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Structure-Activity Relationship
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Thymidylate Synthase
General subdivision antagonists & inhibitors
650 04 - SUBJECT ADDED ENTRY--TOPICAL TERM
Topical term or geographic name entry element Tumor Cells, Cultured
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Kuhnt, D
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Shih, C
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Rinzel, S M
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Grindey, G B
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Barredo, J
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Jannatipour, M
700 1# - ADDED ENTRY--PERSONAL NAME
Personal name Moran, R G
773 0# - HOST ITEM ENTRY
Title Journal of medicinal chemistry
Related parts vol. 35
-- no. 23
-- p. 4450-4
856 40 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="https://doi.org/10.1021/jm00101a023">https://doi.org/10.1021/jm00101a023</a>
Public note Available from publisher's website

No items available.