Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis. [electronic resource]
Producer: 20030711Description: 2376-96 p. digitalISSN:- 0022-2623
- ADAM Proteins
- ADAM17 Protein
- Administration, Oral
- Animals
- Binding Sites
- Biological Assay
- Cartilage -- drug effects
- Cattle
- Crystallography, X-Ray
- Dialysis
- Dogs
- Haplorhini
- Humans
- Hydroxamic Acids -- chemical synthesis
- Male
- Matrix Metalloproteinase 13
- Matrix Metalloproteinase Inhibitors
- Matrix Metalloproteinases -- chemistry
- Metalloendopeptidases -- antagonists & inhibitors
- Mice
- Models, Molecular
- Osteoarthritis -- drug therapy
- Piperidines -- chemical synthesis
- Protease Inhibitors -- chemical synthesis
- Rabbits
- Rats
- Structure-Activity Relationship
- Sulfones -- chemical synthesis
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Publication Type: Journal Article
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