Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.

Aranapakam, Venkatesan

Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis. [electronic resource] - Journal of medicinal chemistry Jun 2003 - 2376-96 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm0205550 doi


ADAM Proteins
ADAM17 Protein
Administration, Oral
Animals
Binding Sites
Biological Assay
Cartilage--drug effects
Cattle
Crystallography, X-Ray
Dialysis
Dogs
Haplorhini
Humans
Hydroxamic Acids--chemical synthesis
Male
Matrix Metalloproteinase 13
Matrix Metalloproteinase Inhibitors
Matrix Metalloproteinases--chemistry
Metalloendopeptidases--antagonists & inhibitors
Mice
Models, Molecular
Osteoarthritis--drug therapy
Piperidines--chemical synthesis
Protease Inhibitors--chemical synthesis
Rabbits
Rats
Structure-Activity Relationship
Sulfones--chemical synthesis