Metabolic activation of o-phenylphenol to a major cytotoxic metabolite, phenylhydroquinone: role of human CYP1A2 and rat CYP2C11/CYP2E1. [electronic resource]
Producer: 20010628Description: 1005-17 p. digitalISSN:- 0049-8254
- Animals
- Aryl Hydrocarbon Hydroxylases
- Biotransformation
- Biphenyl Compounds -- pharmacokinetics
- Cytochrome P-450 CYP1A2 -- metabolism
- Cytochrome P-450 CYP2E1 -- metabolism
- Cytochrome P-450 Enzyme System -- metabolism
- Cytochrome P450 Family 2
- Cytochromes
- Flavonoids
- Humans
- Hydroquinones -- pharmacokinetics
- Hydroxylation
- Isoenzymes -- metabolism
- Kinetics
- Liver Neoplasms, Experimental
- Male
- Microsomes, Liver -- enzymology
- Phenols -- pharmacokinetics
- Polymers -- pharmacokinetics
- Polyphenols
- Rats
- Rats, Inbred F344
- Rats, Sprague-Dawley
- Recombinant Proteins -- metabolism
- Steroid 16-alpha-Hydroxylase
- Steroid Hydroxylases -- metabolism
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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